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FACULTY Department Members By Category Laboratories Faculty Robert Salata, MD Chief Donald Anthony, MD, PhD Keith Armitage, MD Eric Arts, PhD David Bobak, MD Robert Bonomo, MD W. Henry Boom, MD David Canaday, MD Michael Cho, PhD Curtis Donskey, MD Scott Fulton, MD Yong Gao, MD, PhD Barbara Gripshover, MD Marion Helfand, MD Christina Hirsch, MD Marta Jakubowycz, MD Wei Jiang, MD John L Johnson, MD Michael Lederman, MD Tracy Lemonovich, MD Michelle Lisgaris, MD Amy Ray, MD Louis Rice, MD Benigno, Rodriguez, MD Roxana Rojas, MD Scott Sieg, PhD Richard Silver, MD Usha Stiefel, MD Zahra Toossi, MD Gopal Yadavalli, MD Research Staff Administrative Staff SEARCH: RELATED SITES:	Roxana E. Rojas MD, Ph.D. Senior Instructor Phone: (216) 368-4844 Fax: (216) 368-2034 E-mail: rxr38@case.edu Education MD- National University of La Plata, Buenos Aires, Argentina, 1991 PhD- National University of La Plata, Buenos Aires, Argentina, 1998 Research I have been working in Dr W. H. Boom’s laboratory for the past 5 years. The main focus of our laboratory is to study antigen processing and presentation for different T cell subtypes, i.e. CD4+, CD8+ and T cells, in M. tuberculosis infection. We are interested in the role of different M. tuberculosis components in regulation of the antigen processing and presentation machinery. More recently, we became interested in exploring direct modulation of T cell function by M. tuberculosis components. NIH Biosketch Selected Publications • R. E. Rojas, Balaji K. N., Subramanian A. and Boom W. H. 1999. Regulation of human CD4+áâ T-cell-receptor-positive (TCR+) and ãä TCR+ T-cell responses to Mycobacterium tuberculosis by Interleukin-10 and Transforming growth factor-â. Infection and Immunity. 67 (12): 6461-6472. • R. E, Rojas and W. H. Boom. Gamma-delta T cells in HIV-1 infection. Cytometric Cellular Analysis series. 2001 by Wiley- Liss Inc., pp 147- 205. • R. E. Rojas, M. Torres, J.J. Fournie, C.Harding and W.H. Boom. 2002. Phosphoantigen presentation by macrophages to Mycobacterium tuberculosis- reactive V 9V 2 T cells: modulation by chloroquine. Infection and Immunity, 70, (8): 4019-4027. • A. Gehring, R. E. Rojas, C. Harding and W. H. Boom. 2003. The 19kD lipoprotein of Mycobacterium tuberculosis inhibits on antigen processing and presentation by human monocytes Infection and Immunity, 71, (8): 4487– 4497. Shared first authorship.


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