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FACULTY Department Members By Category Laboratories Faculty Robert Salata, MD Chief Donald Anthony, MD, PhD Keith Armitage, MD Eric Arts, PhD David Bobak, MD Robert Bonomo, MD W. Henry Boom, MD David Canaday, MD Michael Cho, PhD Curtis Donskey, MD Scott Fulton, MD Yong Gao, MD, PhD Barbara Gripshover, MD Marion Helfand, MD Christina Hirsch, MD Marta Jakubowycz, MD Wei Jiang, MD John L Johnson, MD Michael Lederman, MD Tracy Lemonovich, MD Michelle Lisgaris, MD Amy Ray, MD Louis Rice, MD Benigno, Rodriguez, MD Roxana Rojas, MD Scott Sieg, PhD Richard Silver, MD Usha Stiefel, MD Zahra Toossi, MD Gopal Yadavalli, MD Research Staff Administrative Staff SEARCH: RELATED SITES:	David Canaday, MD Assistant Professor Phone: (216) 368-8901 Fax: (216) 368-2034 E-mail: dxc44@case.edu Education MD- Washington University, 1992 Residency- University of Minnesota, 1995 Fellowship- Case Western Reserve University / University Hospitals of Cleveland, 1999 Laboratory Research My research interest has focused on immunology of tuberculosis. Specifically I have looked at mechanisms of killing of tuberculosis in macrophages. In addition, I am working on projects including antigen processing in antigen presenting cells from in HIV+ donors. Also, I have a project looking at heat shock proteins a vaccine delivery vehicle. NIH Biosketch Selected References • Canaday DH, Ziebold C, Noss E, Chervenak KA, Harding CV, Boom WH. Activation of human CD8+ + TCR+ T cells by M. tuberculosis via an alternate class I MHC antigen processing pathway. Journal of Immunology. 162:372-9, 1999. • Canaday DH, Wilkinson RJ , Li Q, Clifford V Harding CV, Silver RF, WH Boom. CD4+ and CD8+ T cells kill intracellular M. tuberculosis by a perforin and FAS/FASL independent mechanism. Journal of Immunology. 167:2734-2742, 2001. • Canaday DH, Beigi R, Silver RF, Harding CV, Boom WH, Dubyak GR. ATP and Control of Intracellular Growth of Mycobacteria by T Cells. Infection and Immunity. 2002;70 6456-6459. • Canaday DH, Gehring A, Leonard EG, Eilertson B, Schreiber JR, Harding CV, Boom WH. T cell hybridomas from HLA-transgenic mice as tools for analysis of human antigen processing. Journal of Immunological Methods. 281: 129-142, 2003.


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