Donald Anthony Jr, MD, PhD
Associate Professor of Medicine
Phone: (216368
Fax: (216) 368
E-mail: dda3@case.edu
Foley 407A
Education
MD-Case Western Reserve University
Residency-Case Western Reserve University
Rheumatology Fellowship-Case Western Reserve University
Research
Dr. Anthony’s primary research interests are in the T cell mediated immune mechanisms of human disease. Current work focuses on hepatitis C virus specific CD4 and CD8 T cell immunity in the infected host and how this immunity is related to the clinical manifestations and disease progression, as well as response to therapy. Experiments are aimed at exploring the relationship between the control or resolution of hepatitis C related diseases and the frequency, cytokine producing quality, and the fine antigen specificity of the cellular immune response in infected host.
From this brief description it is evident that members of our faculty are internationally recognized for their work in cartilage homeostasis and degradation, immunogenetics, animal models of RA and OA, and T cell biology.
Selected References:
• Jefferson, K. K., Smith, M. F., and Bobak, D. A. Roles of intracellular calcium and NF-kB in the Clostridium difficile toxin A-induced up-regulation and secretion of IL-8 by human monocytes J. Immunol. 163:5183-5191, 1999.
• Bobak, D. A. and Yadavalli, G. Update on the management of hepatitis C in liver transplant patients. Curr. Infect. Dis. Reports 4:105-111, 2002.
• Bobak, D. A. Gastrointestinal infections caused by cytomegalovirus. Curr. Infect. Dis. Reports 5:101, 2003.
• Guerrant, R. L. and Bobak, D. A. Nausea, vomiting, and non-inflammatory diarrhea, in Principles and Practice of Infectious Diseases, 6th edition, Mandell, G. L., Bennett, J. E., and Dolin, R. eds., Churchill Livingstone, New York, in press
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